Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9897.012 | 0.3764 | -0.7446 | 0.4748 | |
| T47D | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9897.012 | 0.3154 | -0.8240 | 0.4748 | |
| T47D | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9897.012 | 0.3225 | -0.8155 | 0.4748 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9913.012 | 1.0272 | 1.0862 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9913.012 | 1.1056 | 1.3419 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9913.012 | 0.9531 | 0.8545 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9913.012 | 0.4637 | -0.4022 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9913.012 | 0.3842 | -0.5552 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9913.012 | 0.3872 | -0.5497 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9913.012 | 0.3887 | -0.5470 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9913.012 | 0.4153 | -0.4973 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9913.012 | 0.3682 | -0.5839 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10150.012 | 1.0289 | 1.1274 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10150.012 | 1.1043 | 1.4801 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10150.012 | 1.0020 | 1.0089 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10150.012 | 0.5856 | -0.3735 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10150.012 | 0.3951 | -0.7331 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10150.012 | 0.4120 | -0.7077 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10150.012 | 0.3711 | -0.7670 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10150.012 | 0.4202 | -0.6949 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10150.012 | 0.3825 | -0.7512 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10151.012 | 1.0194 | 1.1107 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10151.012 | 1.0798 | 1.4795 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10151.012 | 0.9228 | 0.5974 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10151.012 | 0.5759 | -0.5732 | 0.3572 |