Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10151.012 | 0.3709 | -0.8755 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10151.012 | 0.3830 | -0.8638 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10151.012 | 0.3475 | -0.8962 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10151.012 | 0.3993 | -0.8469 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10151.012 | 0.3606 | -0.8849 | 0.3572 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9933.012 | 0.9315 | 0.6830 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9933.012 | 1.0554 | 1.2799 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9933.012 | 0.9334 | 0.6913 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9933.012 | 0.8103 | 0.1995 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9933.012 | 0.5761 | -0.4766 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9933.012 | 0.3759 | -0.8147 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9933.012 | 0.3120 | -0.8822 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9933.012 | 0.2527 | -0.9294 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9933.012 | 0.1768 | -0.9704 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9953.049 | 1.1119 | 1.4332 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9953.049 | 1.1819 | 1.7238 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9953.049 | 0.9355 | 0.7683 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9953.049 | 0.7862 | 0.2821 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9953.049 | 0.4839 | -0.4771 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9953.049 | 0.4506 | -0.5417 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9953.049 | 0.3441 | -0.7216 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9953.049 | 0.1839 | -0.9126 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9953.049 | 0.1786 | -0.9172 | 0.5411 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7931.04 | 1.0808 | 1.1253 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7931.04 | 1.0681 | 1.1058 | 1.2790 |