Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Etoposide | TOP2 | TOP | 66.7 | uM | 5904.074 | 0.2499 | -0.5245 | 0.9654 | |
| BT-20 | TNBC | Basal A | Etoposide | TOP2 | TOP | 333 | uM | 5904.074 | 0.1642 | -0.6922 | 0.9654 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 5905.074 | 1.0569 | 1.1322 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 5905.074 | 1.0093 | 1.0215 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 5905.074 | 0.9601 | 0.9080 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 5905.074 | 0.9678 | 0.9256 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 5905.074 | 0.9835 | 0.9619 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 5905.074 | 0.9691 | 0.9288 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 5905.074 | 0.8542 | 0.6667 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 5905.074 | 0.5789 | 0.0629 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 5905.074 | 0.4271 | -0.2522 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 5906.074 | 0.8145 | 0.4545 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 5906.074 | 1.0448 | 1.1409 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 5906.074 | 0.9289 | 0.7836 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 5906.074 | 1.0262 | 1.0820 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 5906.074 | 0.8181 | 0.4644 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 5906.074 | 1.0093 | 1.0288 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 5906.074 | 0.8709 | 0.6136 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 5906.074 | 0.5551 | -0.1979 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 5906.074 | 0.3180 | -0.6623 | 0.6442 | |
| BT-483 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 5908.074 | 0.9296 | 0.7391 | 0.5224 | |
| BT-483 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 5908.074 | 0.9397 | 0.7754 | 0.5224 | |
| BT-483 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 5908.074 | 0.9682 | 0.8800 | 0.5224 | |
| BT-483 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 5908.074 | 0.9445 | 0.7929 | 0.5224 | |
| BT-483 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 5908.074 | 0.9161 | 0.6913 | 0.5224 |