Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 2.67 | uM | 7484.09 | 0.4529 | 0.4837 | 2.6525 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 13.3 | uM | 7484.09 | 0.2047 | 0.0998 | 2.6525 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 66.7 | uM | 7484.09 | 0.1393 | -0.0487 | 2.6525 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 0.0000853 | uM | 7485.092 | 1.0297 | 1.0161 | 3.6408 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 0.000427 | uM | 7485.092 | 0.9532 | 0.9738 | 3.6408 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 0.00213 | uM | 7485.092 | 0.9888 | 0.9938 | 3.6408 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 0.0107 | uM | 7485.092 | 0.9836 | 0.9910 | 3.6408 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 0.0533 | uM | 7485.092 | 0.9149 | 0.9517 | 3.6408 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 0.267 | uM | 7485.092 | 0.7859 | 0.8719 | 3.6408 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 1.33 | uM | 7485.092 | 0.4814 | 0.6361 | 3.6408 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 6.67 | uM | 7485.092 | 0.2375 | 0.3475 | 3.6408 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 33.3 | uM | 7485.092 | 0.1597 | 0.2084 | 3.6408 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.0000853 | uM | 7486.092 | 1.0470 | 1.0832 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.000427 | uM | 7486.092 | 1.0464 | 1.0821 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.00213 | uM | 7486.092 | 1.0348 | 1.0617 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.0107 | uM | 7486.092 | 1.0155 | 1.0275 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.0533 | uM | 7486.092 | 1.0744 | 1.1315 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.267 | uM | 7486.092 | 0.7364 | 0.5244 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 1.33 | uM | 7486.092 | 0.5169 | 0.1133 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 6.67 | uM | 7486.092 | 0.4227 | -0.0687 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 33.3 | uM | 7486.092 | 0.2943 | -0.3248 | 1.1266 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.000171 | uM | 7487.09 | 1.0235 | 1.0307 | 1.5226 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.000853 | uM | 7487.09 | 1.0285 | 1.0373 | 1.5226 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.00427 | uM | 7487.09 | 1.0223 | 1.0291 | 1.5226 | |
| MCF 10F | NM | - | Erlotinib | EGFR | ErbB | 0.0213 | uM | 7487.09 | 1.0205 | 1.0268 | 1.5226 |