Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 7886.017 | 0.4499 | -0.3375 | 0.7230 | |
| MDA-MB-175-VII | HR+ | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 7886.017 | 0.5172 | -0.1966 | 0.7230 | |
| MDA-MB-175-VII | HR+ | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7886.017 | 0.2560 | -0.6963 | 0.7230 | |
| MDA-MB-175-VII | HR+ | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7886.017 | 0.0006 | -0.9999 | 0.7230 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7892.017 | 1.0015 | 1.0012 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7892.017 | 1.0510 | 1.0410 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.011 | uM | 7892.017 | 1.0256 | 1.0207 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7892.017 | 0.8929 | 0.9096 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.276 | uM | 7892.017 | 0.7720 | 0.7995 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 1.38 | uM | 7892.017 | 0.1769 | -0.0140 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 6.9 | uM | 7892.017 | 0.1317 | -0.1258 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 34.5 | uM | 7892.017 | 0.1199 | -0.1587 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7892.017 | 0.0003 | -0.9294 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7893.017 | 1.0761 | 1.0651 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7893.017 | 0.9912 | 0.9923 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.011 | uM | 7893.017 | 1.0058 | 1.0050 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7893.017 | 1.0239 | 1.0208 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.276 | uM | 7893.017 | 0.7393 | 0.7528 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 1.38 | uM | 7893.017 | 0.1035 | -0.2574 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 6.9 | uM | 7893.017 | 0.1697 | -0.0783 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 34.5 | uM | 7893.017 | 0.1360 | -0.1631 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7893.017 | 0.0006 | -0.9244 | 2.2898 | |
| MDA-MB-361 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7896.017 | 1.0240 | 1.0474 | 1.0113 | |
| MDA-MB-361 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7896.017 | 1.0349 | 1.0689 | 1.0113 | |
| MDA-MB-361 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 7896.017 | 1.0724 | 1.1431 | 1.0113 |