Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 34.5 | uM | 9386.017 | 0.0322 | -0.8383 | 1.3666 | |
| HCC1954 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 172 | uM | 9386.017 | 0.0044 | -0.9624 | 1.3666 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7846.017 | 1.0055 | 1.0326 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7846.017 | 1.0093 | 1.0550 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 7846.017 | 1.0425 | 1.2603 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7846.017 | 0.9245 | 0.5881 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 7846.017 | 0.8097 | 0.0754 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 7846.017 | 0.5819 | -0.5926 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 7846.017 | 0.1821 | -0.9866 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7846.017 | 0.0677 | -0.9993 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7846.017 | 0.0018 | -1.0000 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7848.017 | 1.0275 | 1.1758 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7848.017 | 1.0239 | 1.1522 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 7848.017 | 1.0552 | 1.3627 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7848.017 | 0.9432 | 0.6686 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 7848.017 | 0.8898 | 0.3923 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 7848.017 | 0.6260 | -0.5319 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 7848.017 | 0.4075 | -0.8763 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7848.017 | 0.2099 | -0.9842 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7848.017 | 0.0040 | -1.0000 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7849.017 | 0.9914 | 0.9507 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7849.017 | 1.0510 | 1.3082 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 7849.017 | 1.0314 | 1.1865 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7849.017 | 0.9654 | 0.8068 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 7849.017 | 0.8628 | 0.3073 | 0.3471 |