Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 92 | uM | 10266.121 | 0.3163 | -0.6038 | 0.7110 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9708.121 | 1.0698 | 1.1220 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9708.121 | 1.0242 | 1.0424 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9708.121 | 1.0393 | 1.0688 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9708.121 | 0.9585 | 0.9270 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9708.121 | 0.8366 | 0.7102 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9708.121 | 0.0708 | -0.8041 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9708.121 | 0.0832 | -0.7744 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9708.121 | 0.0613 | -0.8276 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9708.121 | 0.0007 | -0.9966 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9723.121 | 1.1280 | 1.2720 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9723.121 | 0.9399 | 0.8729 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9723.121 | 1.1454 | 1.3092 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9723.121 | 1.0325 | 1.0690 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9723.121 | 0.9015 | 0.7921 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9723.121 | 0.1669 | -0.6994 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9723.121 | 0.1058 | -0.8145 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9723.121 | 0.0543 | -0.9085 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9723.121 | 0.0060 | -0.9910 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 10270.121 | 0.8794 | 0.7110 | 0.8235 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 10270.121 | 0.9082 | 0.7794 | 0.8235 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 10270.121 | 0.9451 | 0.8675 | 0.8235 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 10270.121 | 0.8319 | 0.5994 | 0.8235 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 10270.121 | 0.8900 | 0.7362 | 0.8235 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 10270.121 | 0.1670 | -0.7724 | 0.8235 |