Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10818.155 | 0.8798 | 0.6183 | 0.6048 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10818.155 | 0.9712 | 0.9058 | 0.6048 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10818.155 | 0.8472 | 0.5205 | 0.6048 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10818.155 | 0.3898 | -0.5788 | 0.6048 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10818.155 | 0.3412 | -0.6621 | 0.6048 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10818.155 | 0.4858 | -0.3938 | 0.6048 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12126.155 | 0.9588 | 0.8799 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12126.155 | 0.9238 | 0.7799 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12126.155 | 0.9443 | 0.8383 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12126.155 | 0.9301 | 0.7979 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12126.155 | 0.9204 | 0.7703 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12126.155 | 0.8519 | 0.5800 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12126.155 | 0.3369 | -0.5963 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12126.155 | 0.9199 | 0.7688 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12126.155 | 0.8859 | 0.6736 | 0.6799 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10643.146 | 1.0583 | 1.1842 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10643.146 | 1.0274 | 1.0857 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10643.146 | 1.0443 | 1.1392 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10643.146 | 1.0528 | 1.1663 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10643.146 | 0.9982 | 0.9945 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10643.146 | 0.9822 | 0.9451 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10643.146 | 0.8436 | 0.5357 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10643.146 | 0.3383 | -0.6287 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10643.146 | 0.6268 | -0.0321 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10999.155 | 1.0890 | 1.2454 | 0.7370 |