Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 12084.155 | 1.0017 | 1.0027 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 12084.155 | 0.4788 | 0.1327 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 12084.155 | 0.9353 | 0.8993 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 12084.155 | 0.9070 | 0.8548 | 1.2955 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12001.155 | 0.9635 | 0.8794 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12001.155 | 0.9536 | 0.8471 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12001.155 | 0.9186 | 0.7349 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12001.155 | 0.9439 | 0.8157 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12001.155 | 0.8580 | 0.5476 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12001.155 | 0.6085 | -0.1293 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12001.155 | 0.5266 | -0.3166 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12001.155 | 0.8443 | 0.5065 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12001.155 | 0.7269 | 0.1725 | 0.5973 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10693.146 | 1.0059 | 1.0133 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10693.146 | 0.9440 | 0.8735 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10693.146 | 0.9786 | 0.9516 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10693.146 | 0.9784 | 0.9512 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10693.146 | 0.9708 | 0.9339 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10693.146 | 0.9656 | 0.9222 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10693.146 | 0.9632 | 0.9169 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10693.146 | 0.9422 | 0.8694 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10693.146 | 0.9644 | 0.9195 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11936.155 | 0.9925 | 0.9796 | 0.7332 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11936.155 | 0.9831 | 0.9542 | 0.7332 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11936.155 | 1.0225 | 1.0615 | 0.7332 |