Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 10073.034 | 1.0087 | 1.0315 | 0.5531 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10073.034 | 0.9963 | 0.9868 | 0.5531 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10073.034 | 0.9923 | 0.9721 | 0.5531 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 10073.034 | 0.9974 | 0.9904 | 0.5531 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 10073.034 | 0.9885 | 0.9585 | 0.5531 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 10073.034 | 0.9857 | 0.9484 | 0.5531 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 10073.034 | 0.9313 | 0.7585 | 0.5531 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 10073.034 | 0.3196 | -0.7457 | 0.5531 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7876.007 | 1.0799 | 1.1559 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7876.007 | 1.0416 | 1.0812 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7876.007 | 1.0414 | 1.0808 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7876.007 | 1.0789 | 1.1539 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7876.007 | 1.0193 | 1.0377 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7876.007 | 0.9509 | 0.9040 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7876.007 | 0.7274 | 0.4660 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7876.007 | 0.6803 | 0.3732 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7876.007 | 0.6145 | 0.2435 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7877.007 | 0.9822 | 0.9408 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7877.007 | 1.0350 | 1.1186 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7877.007 | 1.2324 | 1.8369 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7877.007 | 0.9364 | 0.7917 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7877.007 | 1.0171 | 1.0574 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7877.007 | 0.8331 | 0.4733 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7877.007 | 0.6303 | -0.0760 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7877.007 | 0.5729 | -0.2124 | 0.5977 |