Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7877.007 | 0.4990 | -0.3750 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 10077.121 | 1.0384 | 1.1606 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 10077.121 | 1.1679 | 1.7500 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 10077.121 | 1.0002 | 1.0007 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 10077.121 | 1.0959 | 1.4132 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 10077.121 | 1.1134 | 1.4931 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 10077.121 | 1.0422 | 1.1770 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 10077.121 | 1.0458 | 1.1926 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 10077.121 | 0.8859 | 0.5599 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 10077.121 | 0.6046 | -0.2875 | 0.4875 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7879.077 | 1.0047 | 1.0050 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7879.077 | 1.0311 | 1.0333 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7879.077 | 0.9512 | 0.9468 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7879.077 | 1.0389 | 1.0416 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 7879.077 | 0.9931 | 0.9925 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 7879.077 | 0.9253 | 0.9180 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 7879.077 | 0.8527 | 0.8353 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 7879.077 | 0.8311 | 0.8100 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 7879.077 | 0.0624 | -0.5525 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000189 | uM | 10093.034 | 1.0137 | 1.0282 | 0.9732 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000945 | uM | 10093.034 | 1.0388 | 1.0797 | 0.9732 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10093.034 | 1.0110 | 1.0227 | 0.9732 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10093.034 | 1.0655 | 1.1348 | 0.9732 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 10093.034 | 1.0327 | 1.0671 | 0.9732 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 10093.034 | 0.8924 | 0.7792 | 0.9732 |