Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.59 | uM | 7872.007 | 0.8463 | 0.8143 | 1.7126 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 2.95 | uM | 7872.007 | 0.6964 | 0.6190 | 1.7126 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 14.8 | uM | 7872.007 | 0.5223 | 0.3688 | 1.7126 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 73.8 | uM | 7872.007 | 0.2453 | -0.1196 | 1.7126 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9566.121 | 1.1031 | 1.0868 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9566.121 | 1.0119 | 1.0103 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9566.121 | 1.0535 | 1.0456 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9566.121 | 1.0315 | 1.0271 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.136 | uM | 9566.121 | 1.0053 | 1.0046 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.682 | uM | 9566.121 | 0.8945 | 0.9057 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 3.41 | uM | 9566.121 | 0.6644 | 0.6754 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 17.1 | uM | 9566.121 | 0.4918 | 0.4708 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 85.2 | uM | 9566.121 | 0.3098 | 0.2040 | 2.3089 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7491.078 | 0.9972 | 0.9924 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7491.078 | 0.9945 | 0.9847 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7491.078 | 0.9899 | 0.9721 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7491.078 | 0.9559 | 0.8792 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 7491.078 | 0.9404 | 0.8373 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 7491.078 | 0.8372 | 0.5645 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 7491.078 | 0.7543 | 0.3547 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 7491.078 | 0.5101 | -0.2108 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 7491.078 | 0.2526 | -0.7011 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 10061.121 | 1.1012 | 1.1021 | 1.9364 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 10061.121 | 1.0588 | 1.0599 | 1.9364 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 10061.121 | 1.0642 | 1.0653 | 1.9364 |