Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 10031.034 | 1.0088 | 1.0219 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 10031.034 | 1.0427 | 1.1064 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10031.034 | 1.0575 | 1.1435 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10031.034 | 1.0157 | 1.0389 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 10031.034 | 1.0282 | 1.0703 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 10031.034 | 1.0614 | 1.1533 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 10031.034 | 0.9613 | 0.9044 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 10031.034 | 0.8914 | 0.7342 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 10031.034 | 0.3080 | -0.5356 | 0.8064 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7825.007 | 0.9229 | 0.8971 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7825.007 | 1.0033 | 1.0043 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7825.007 | 1.1123 | 1.1451 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7825.007 | 1.0534 | 1.0696 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 7825.007 | 1.0051 | 1.0067 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 7825.007 | 0.9470 | 0.9296 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 7825.007 | 1.0150 | 1.0197 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 7825.007 | 0.9993 | 0.9990 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 73.8 | uM | 7825.007 | 0.8618 | 0.8135 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9347.121 | 1.0743 | 1.1012 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9347.121 | 1.0918 | 1.1247 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9347.121 | 1.0417 | 1.0570 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9347.121 | 1.0517 | 1.0707 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.136 | uM | 9347.121 | 1.0120 | 1.0165 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.682 | uM | 9347.121 | 1.0342 | 1.0468 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 3.41 | uM | 9347.121 | 0.9642 | 0.9505 | 1.4523 |