Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.16 | uM | 9723.049 | 0.9667 | 0.9301 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.8 | uM | 9723.049 | 1.1161 | 1.2445 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 4 | uM | 9723.049 | 0.9995 | 0.9990 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 20 | uM | 9723.049 | 1.1053 | 1.2218 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 100 | uM | 9723.049 | 1.1676 | 1.3534 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 500 | uM | 9723.049 | 1.0071 | 1.0150 | 0.9525 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7904.017 | 1.1384 | 1.1937 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7904.017 | 0.9536 | 0.9333 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7904.017 | 1.1878 | 1.2612 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7904.017 | 1.0021 | 1.0030 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7904.017 | 1.0850 | 1.1198 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7904.017 | 0.8497 | 0.7806 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7904.017 | 0.4828 | 0.1899 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7904.017 | 0.2308 | -0.2970 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7904.017 | 0.7462 | 0.6231 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7905.035 | 1.0995 | 1.2336 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7905.035 | 0.7258 | 0.3771 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7905.035 | 1.0423 | 1.0988 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7905.035 | 0.8510 | 0.6574 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7905.035 | 1.0738 | 1.1730 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7905.035 | 0.6895 | 0.2972 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7905.035 | 0.5426 | -0.0186 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7905.035 | 0.0378 | -0.9559 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7905.035 | 0.0020 | -0.9986 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7906.017 | 1.3773 | 3.6223 | 0.3822 |