Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9566.017 | 0.7455 | 0.7472 | 2.1734 | |
| MCF 10F | NM | - | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9566.017 | 0.2952 | 0.1409 | 2.1734 | |
| MCF 10F | NM | - | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9566.017 | 0.0217 | -0.6570 | 2.1734 | |
| MCF 10F | NM | - | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9566.017 | 0.0019 | -0.8879 | 2.1734 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7873.017 | 1.0237 | 1.0214 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7873.017 | 1.0268 | 1.0241 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7873.017 | 1.0478 | 1.0427 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7873.017 | 1.0101 | 1.0092 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7873.017 | 0.9927 | 0.9934 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7873.017 | 0.8387 | 0.8468 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7873.017 | 0.6051 | 0.5930 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7873.017 | 0.0438 | -0.5153 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7873.017 | 0.0063 | -0.7985 | 2.2073 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00128 | uM | 10061.049 | 0.9888 | 0.9874 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0064 | uM | 10061.049 | 1.0011 | 1.0012 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.032 | uM | 10061.049 | 1.0376 | 1.0418 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.16 | uM | 10061.049 | 0.9735 | 0.9701 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.8 | uM | 10061.049 | 1.0310 | 1.0346 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 4 | uM | 10061.049 | 1.0274 | 1.0305 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 20 | uM | 10061.049 | 1.0053 | 1.0059 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 100 | uM | 10061.049 | 1.0400 | 1.0444 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 500 | uM | 10061.049 | 0.9102 | 0.8972 | 1.7845 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7875.017 | 0.9517 | 0.9395 | 1.6110 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7875.017 | 0.9872 | 0.9840 | 1.6110 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7875.017 | 1.0168 | 1.0208 | 1.6110 |