Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9566.011 | 0.0447 | -0.4714 | 2.3358 | |
| MCF 10F | NM | - | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9566.011 | 0.0056 | -0.7823 | 2.3358 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7873.011 | 1.0507 | 1.0481 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7873.011 | 1.0299 | 1.0285 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7873.011 | 1.0007 | 1.0006 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7873.011 | 1.0242 | 1.0231 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 7873.011 | 0.9823 | 0.9829 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 7873.011 | 0.9353 | 0.9367 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 7873.011 | 0.6602 | 0.6383 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 7873.011 | 0.0953 | -0.3537 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 7873.011 | 0.0094 | -0.7879 | 2.0810 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 10061.12 | 1.0070 | 1.0067 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 10061.12 | 0.9744 | 0.9750 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 10061.12 | 1.0735 | 1.0698 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 10061.12 | 0.9847 | 0.9851 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 10061.12 | 1.0081 | 1.0078 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 10061.12 | 0.9520 | 0.9530 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 10061.12 | 0.7908 | 0.7853 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 10061.12 | 0.4144 | 0.3059 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 10061.12 | 0.0125 | -0.7598 | 2.0669 | |
| MCF7 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7875.011 | 0.9362 | 0.9237 | 1.6960 | |
| MCF7 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7875.011 | 0.9655 | 0.9590 | 1.6960 | |
| MCF7 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7875.011 | 0.9570 | 0.9488 | 1.6960 | |
| MCF7 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7875.011 | 0.9198 | 0.9038 | 1.6960 | |
| MCF7 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 7875.011 | 1.0346 | 1.0405 | 1.6960 |