Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0533 | uM | 12319.17 | 0.9906 | 0.9601 | 0.4684 | |
| LY2 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.267 | uM | 12319.17 | 1.1817 | 1.8564 | 0.4684 | |
| LY2 | HR+ | Luminal | Bosutinib | Src | nRTK | 1.33 | uM | 12319.17 | 0.9611 | 0.8374 | 0.4684 | |
| LY2 | HR+ | Luminal | Bosutinib | Src | nRTK | 6.67 | uM | 12319.17 | 0.3732 | -0.7562 | 0.4684 | |
| LY2 | HR+ | Luminal | Bosutinib | Src | nRTK | 33.3 | uM | 12319.17 | 0.3901 | -0.7320 | 0.4684 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.0000853 | uM | 12580.17 | 1.0198 | 1.0197 | 1.9993 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.000427 | uM | 12580.17 | 1.0314 | 1.0312 | 1.9993 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.00213 | uM | 12580.17 | 1.0214 | 1.0213 | 1.9993 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.0107 | uM | 12580.17 | 0.9585 | 0.9581 | 1.9993 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.0533 | uM | 12580.17 | 0.8359 | 0.8285 | 1.9993 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.267 | uM | 12580.17 | 0.4236 | 0.3015 | 1.9993 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 1.33 | uM | 12580.17 | 0.3430 | 0.1712 | 1.9993 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 6.67 | uM | 12580.17 | 0.0435 | -0.5832 | 1.9993 | |
| MB 157 | Unknown | Unknown | Bosutinib | Src | nRTK | 33.3 | uM | 12580.17 | 0.0345 | -0.6288 | 1.9993 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 0.000256 | uM | 11056.145 | 1.0363 | 1.0253 | 2.8383 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 0.00128 | uM | 11056.145 | 1.0546 | 1.0378 | 2.8383 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 0.0064 | uM | 11056.145 | 0.9788 | 0.9850 | 2.8383 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 0.032 | uM | 11056.145 | 1.0657 | 1.0453 | 2.8383 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 0.16 | uM | 11056.145 | 1.1031 | 1.0704 | 2.8383 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 0.8 | uM | 11056.145 | 0.7359 | 0.7952 | 2.8383 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 4 | uM | 11056.145 | 0.2048 | 0.1440 | 2.8383 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 20 | uM | 11056.145 | 0.1453 | 0.0137 | 2.8383 | |
| MCF 10A | NM | Basal B | Bosutinib | Src | nRTK | 100 | uM | 11056.145 | 0.1095 | -0.0825 | 2.8383 | |
| MCF 10F | NM | - | Bosutinib | Src | nRTK | 0.000256 | uM | 12254.145 | 1.0602 | 1.0665 | 1.7869 | |
| MCF 10F | NM | - | Bosutinib | Src | nRTK | 0.00128 | uM | 12254.145 | 1.0045 | 1.0050 | 1.7869 |