Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7536.016 | 1.0956 | 1.3060 | 0.6413 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7536.016 | 0.9595 | 0.8752 | 0.6413 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7536.016 | 0.8330 | 0.5041 | 0.6413 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7536.016 | 0.4614 | -0.4012 | 0.6413 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7536.016 | 0.6946 | 0.1331 | 0.6413 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7536.016 | 0.4799 | -0.3635 | 0.6413 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9860.019 | 1.0144 | 1.0169 | 1.6927 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 9860.019 | 0.9474 | 0.9371 | 1.6927 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 9860.019 | 0.9528 | 0.9437 | 1.6927 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9860.019 | 0.9629 | 0.9558 | 1.6927 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 9860.019 | 0.8824 | 0.8575 | 1.6927 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 9860.019 | 0.8221 | 0.7815 | 1.6927 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 9860.019 | 0.5437 | 0.3953 | 1.6927 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9860.019 | 0.4669 | 0.2752 | 1.6927 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9860.019 | 0.0081 | -0.8836 | 1.6927 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7538.016 | 0.6183 | 0.2826 | 1.0824 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7538.016 | 0.8318 | 0.6871 | 1.0824 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7538.016 | 0.6101 | 0.2671 | 1.0824 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7538.016 | 0.8016 | 0.6304 | 1.0824 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7538.016 | 0.6897 | 0.4190 | 1.0824 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7538.016 | 0.7242 | 0.4844 | 1.0824 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7538.016 | 0.4763 | 0.0079 | 1.0824 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7538.016 | 0.5970 | 0.2419 | 1.0824 | ||
| SUM44PE | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7538.016 | 0.3922 | -0.1577 | 1.0824 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7540.016 | 0.9691 | 0.9347 | 0.9455 |