Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7456.065 | 0.0581 | -0.5213 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7456.065 | 0.0398 | -0.6044 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7457.065 | 0.9005 | 0.8722 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7457.065 | 1.0184 | 1.0231 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7457.065 | 1.0967 | 1.1198 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7457.065 | 1.1132 | 1.1398 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7457.065 | 0.8593 | 0.8177 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7457.065 | 0.5740 | 0.4097 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7457.065 | 0.2010 | -0.2724 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7457.065 | 0.0379 | -0.7455 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7457.065 | 0.0156 | -0.8547 | 1.5870 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7458.065 | 0.9562 | 0.8260 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7458.065 | 1.0255 | 1.1050 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7458.065 | 1.0336 | 1.1389 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7458.065 | 0.9771 | 0.9078 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7458.065 | 0.7172 | 0.0172 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7458.065 | 0.0854 | -0.9866 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7458.065 | 0.0131 | -0.9997 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7458.065 | 0.0128 | -0.9997 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7458.065 | 0.0104 | -0.9998 | 0.4917 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7462.065 | 0.9806 | 0.9034 | 0.3950 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7462.065 | 0.9618 | 0.8120 | 0.3950 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7462.065 | 0.9475 | 0.7447 | 0.3950 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7462.065 | 0.9927 | 0.9634 | 0.3950 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7462.065 | 0.9267 | 0.6495 | 0.3950 |