Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7444.065 | 0.8437 | 0.5906 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7444.065 | 0.1293 | -0.8732 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7444.065 | 0.0174 | -0.9915 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7444.065 | 0.0164 | -0.9922 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7444.065 | 0.0149 | -0.9931 | 0.7419 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7448.065 | 0.9921 | 0.9940 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7448.065 | 0.9914 | 0.9934 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7448.065 | 0.9860 | 0.9892 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7448.065 | 0.9712 | 0.9778 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7448.065 | 0.8276 | 0.8601 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7448.065 | 0.4984 | 0.5318 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7448.065 | 0.1173 | -0.1200 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7448.065 | 0.0638 | -0.3032 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7448.065 | 0.0562 | -0.3359 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7449.065 | 0.9174 | 0.9187 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7449.065 | 1.0454 | 1.0432 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7449.065 | 1.0174 | 1.0167 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7449.065 | 0.9787 | 0.9793 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7449.065 | 0.8903 | 0.8912 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7449.065 | 0.4506 | 0.3624 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7449.065 | 0.1373 | -0.2314 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7449.065 | 0.0536 | -0.5115 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7449.065 | 0.0422 | -0.5646 | 2.0765 | |
| HCC1806 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7450.065 | 0.9387 | 0.9485 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7450.065 | 0.9862 | 0.9886 | 2.4231 |