Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 11936.143 | 1.0150 | 1.0377 | 0.7979 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 11936.143 | 0.9472 | 0.8687 | 0.7979 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 11936.143 | 0.9154 | 0.7902 | 0.7979 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 11936.143 | 0.8577 | 0.6500 | 0.7979 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 11936.143 | 0.1643 | -0.7921 | 0.7979 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 11936.143 | 0.0177 | -0.9873 | 0.7979 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10872.143 | 1.0002 | 1.0002 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 10872.143 | 0.9613 | 0.9524 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 10872.143 | 0.9467 | 0.9341 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 10872.143 | 0.9698 | 0.9628 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 10872.143 | 0.9755 | 0.9699 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 10872.143 | 0.9693 | 0.9623 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 600 | uM | 10872.143 | 0.8277 | 0.7817 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 3000 | uM | 10872.143 | 0.4868 | 0.2881 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 10872.143 | 0.0690 | -0.6096 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12523.143 | 1.0263 | 1.0542 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 12523.143 | 0.9831 | 0.9652 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 12523.143 | 0.9912 | 0.9819 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 12523.143 | 0.9856 | 0.9703 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 12523.143 | 0.9514 | 0.9000 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 12523.143 | 0.9700 | 0.9381 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 600 | uM | 12523.143 | 0.8718 | 0.7362 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 3000 | uM | 12523.143 | 0.6598 | 0.3028 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 12523.143 | 0.1323 | -0.7515 | 0.9700 | |
| HCC1806 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12239.143 | 0.8291 | 0.8313 | 2.1267 |