Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 120 | uM | 12084.143 | 0.9744 | 0.9620 | 1.3499 | |
| HCC1395 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 600 | uM | 12084.143 | 0.9950 | 0.9926 | 1.3499 | |
| HCC1395 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 3000 | uM | 12084.143 | 0.8420 | 0.7607 | 1.3499 | |
| HCC1395 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 15000 | uM | 12084.143 | 0.2332 | -0.3199 | 1.3499 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12001.143 | 0.9179 | 0.7403 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12001.143 | 0.9233 | 0.7568 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12001.143 | 1.0178 | 1.0580 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12001.143 | 1.0107 | 1.0347 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12001.143 | 0.9016 | 0.6904 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12001.143 | 0.9571 | 0.8626 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12001.143 | 0.8994 | 0.6838 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12001.143 | 0.6185 | -0.0830 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12001.143 | 0.0725 | -0.9717 | 0.6160 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10693.143 | 1.0062 | 1.0166 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10693.143 | 0.9747 | 0.9328 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10693.143 | 1.0044 | 1.0118 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10693.143 | 1.0080 | 1.0212 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10693.143 | 0.9945 | 0.9855 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10693.143 | 0.9560 | 0.8836 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10693.143 | 0.8277 | 0.5547 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10693.143 | 0.1260 | -0.8733 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10693.143 | 0.0186 | -0.9901 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 11936.143 | 0.9336 | 0.8350 | 0.7979 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 11936.143 | 0.9274 | 0.8197 | 0.7979 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 11936.143 | 0.9685 | 0.9213 | 0.7979 |