Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 1.33 | uM | 10581.072 | 0.9773 | 0.9567 | 1.0484 | |
| BT-20 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 6.67 | uM | 10581.072 | 0.9569 | 0.9177 | 1.0484 | |
| BT-20 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 33.3 | uM | 10581.072 | 0.9668 | 0.9366 | 1.0484 | |
| BT-20 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 167 | uM | 10581.072 | 0.8013 | 0.6190 | 1.0484 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.000427 | uM | 5905.073 | 1.0814 | 1.1905 | 0.8600 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 5905.073 | 1.0183 | 1.0425 | 0.8600 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0107 | uM | 5905.073 | 1.0450 | 1.1051 | 0.8600 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0533 | uM | 5905.073 | 1.0418 | 1.0975 | 0.8600 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.267 | uM | 5905.073 | 1.0227 | 1.0530 | 0.8600 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 1.33 | uM | 5905.073 | 1.0366 | 1.0855 | 0.8600 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 6.67 | uM | 5905.073 | 1.0653 | 1.1525 | 0.8600 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 33.3 | uM | 5905.073 | 0.9763 | 0.9450 | 0.8600 | |
| BT-474 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 167 | uM | 5905.073 | 0.7629 | 0.4601 | 0.8600 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.000427 | uM | 10696.072 | 1.0030 | 1.0129 | 0.4643 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 10696.072 | 0.9089 | 0.6282 | 0.4643 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0107 | uM | 10696.072 | 1.0078 | 1.0338 | 0.4643 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0533 | uM | 10696.072 | 0.9681 | 0.8653 | 0.4643 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.267 | uM | 10696.072 | 0.9953 | 0.9798 | 0.4643 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 1.33 | uM | 10696.072 | 0.9556 | 0.8137 | 0.4643 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 6.67 | uM | 10696.072 | 0.9834 | 0.9292 | 0.4643 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 33.3 | uM | 10696.072 | 0.9050 | 0.6132 | 0.4643 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 167 | uM | 10696.072 | 0.6676 | -0.1623 | 0.4643 | |
| BT-549 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 0.000427 | uM | 5909.072 | 1.0286 | 1.0192 | 2.9441 | |
| BT-549 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 5909.072 | 1.0125 | 1.0084 | 2.9441 | |
| BT-549 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 0.0107 | uM | 5909.072 | 0.9535 | 0.9679 | 2.9441 |