Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12365.165 | 0.9940 | 0.9937 | 1.9114 | |
| MCF12A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12365.165 | 1.0355 | 1.0368 | 1.9114 | |
| MCF12A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.267 | uM | 12365.165 | 1.0330 | 1.0343 | 1.9114 | |
| MCF12A | NM | Basal B | AS-252424 | PI3K | PI3K | 1.33 | uM | 12365.165 | 1.0305 | 1.0317 | 1.9114 | |
| MCF12A | NM | Basal B | AS-252424 | PI3K | PI3K | 6.67 | uM | 12365.165 | 1.0481 | 1.0498 | 1.9114 | |
| MCF12A | NM | Basal B | AS-252424 | PI3K | PI3K | 33.3 | uM | 12365.165 | 0.6043 | 0.5367 | 1.9114 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10997.153 | 0.9461 | 0.8998 | 1.0771 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10997.153 | 0.9174 | 0.8462 | 1.0771 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10997.153 | 0.9553 | 0.9169 | 1.0771 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10997.153 | 1.0022 | 1.0040 | 1.0771 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10997.153 | 0.9496 | 0.9063 | 1.0771 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 10997.153 | 0.9687 | 0.9418 | 1.0771 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 10997.153 | 0.9280 | 0.8659 | 1.0771 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10997.153 | 0.8388 | 0.6989 | 1.0771 | |
| MCF7 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10997.153 | 0.6506 | 0.3418 | 1.0771 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10519.141 | 1.0125 | 1.0240 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10519.141 | 0.9808 | 0.9632 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 10519.141 | 1.0127 | 1.0244 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 10519.141 | 1.0288 | 1.0552 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 10519.141 | 0.9921 | 0.9848 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 10519.141 | 0.9690 | 0.9405 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 10519.141 | 0.9568 | 0.9170 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 10519.141 | 0.7148 | 0.4489 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 10519.141 | 0.6191 | 0.2621 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10998.153 | 0.9946 | 0.9855 | 0.7434 |