Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 33.3 | uM | 7892.016 | 0.9812 | 0.9839 | 2.3475 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 167 | uM | 7892.016 | 1.0928 | 1.0771 | 2.3475 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.000427 | uM | 7893.016 | 0.9922 | 0.9929 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.00213 | uM | 7893.016 | 1.0303 | 1.0273 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.0107 | uM | 7893.016 | 1.0109 | 1.0098 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.0533 | uM | 7893.016 | 1.0015 | 1.0014 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.267 | uM | 7893.016 | 0.9715 | 0.9740 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 1.33 | uM | 7893.016 | 1.0702 | 1.0624 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 6.67 | uM | 7893.016 | 0.9899 | 0.9908 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 33.3 | uM | 7893.016 | 1.0035 | 1.0032 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 167 | uM | 7893.016 | 1.0574 | 1.0513 | 2.2064 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7505.016 | 0.9923 | 0.9856 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7505.016 | 1.0207 | 1.0386 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7505.016 | 1.0208 | 1.0387 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7505.016 | 1.0175 | 1.0327 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7505.016 | 1.0241 | 1.0449 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 7505.016 | 1.0142 | 1.0266 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 7505.016 | 0.8635 | 0.7442 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 7505.016 | 0.6745 | 0.3852 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 7505.016 | 0.6630 | 0.3631 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7894.016 | 0.9891 | 0.9719 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7894.016 | 1.0165 | 1.0427 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7894.016 | 0.9886 | 0.9705 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7894.016 | 0.9753 | 0.9365 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7894.016 | 0.9607 | 0.8993 | 0.7753 |