Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.016 | uM | 10694.152 | 0.6864 | 0.7124 | 2.4238 | |
| Hs 578T | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.08 | uM | 10694.152 | 0.9545 | 0.9620 | 2.4238 | |
| Hs 578T | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.4 | uM | 10694.152 | 0.9627 | 0.9689 | 2.4238 | |
| Hs 578T | TNBC | Basal B | PD 98059 | MEK | MAPK | 2 | uM | 10694.152 | 0.9342 | 0.9446 | 2.4238 | |
| Hs 578T | TNBC | Basal B | PD 98059 | MEK | MAPK | 10 | uM | 10694.152 | 0.8733 | 0.8913 | 2.4238 | |
| Hs 578T | TNBC | Basal B | PD 98059 | MEK | MAPK | 50 | uM | 10694.152 | 0.7909 | 0.8155 | 2.4238 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 10816.152 | 0.9833 | 0.9670 | 1.0111 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 10816.152 | 0.9661 | 0.9329 | 1.0111 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 10816.152 | 1.0063 | 1.0124 | 1.0111 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 10816.152 | 0.8568 | 0.7166 | 1.0111 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 10816.152 | 0.9712 | 0.9429 | 1.0111 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 10816.152 | 0.9896 | 0.9795 | 1.0111 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 10816.152 | 1.0372 | 1.0735 | 1.0111 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 10816.152 | 1.0345 | 1.0683 | 1.0111 | |
| LY2 | HR+ | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 10816.152 | 0.8008 | 0.6055 | 1.0111 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.000128 | uM | 12580.152 | 1.0082 | 1.0072 | 2.2597 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.00064 | uM | 12580.152 | 0.9927 | 0.9935 | 2.2597 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.0032 | uM | 12580.152 | 0.9857 | 0.9873 | 2.2597 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.016 | uM | 12580.152 | 1.0276 | 1.0243 | 2.2597 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.08 | uM | 12580.152 | 0.9914 | 0.9924 | 2.2597 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.4 | uM | 12580.152 | 0.9972 | 0.9975 | 2.2597 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 2 | uM | 12580.152 | 1.0320 | 1.0281 | 2.2597 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 10 | uM | 12580.152 | 0.9573 | 0.9617 | 2.2597 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 50 | uM | 12580.152 | 0.8026 | 0.8145 | 2.2597 | |
| MCF 10A | NM | Basal B | PD 98059 | MEK | MAPK | 0.000128 | uM | 11056.152 | 0.9306 | 0.9522 | 2.9748 |