Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7794.016 | 0.9589 | 0.9575 | 1.9541 | |
| AU565 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7794.016 | 1.0080 | 1.0081 | 1.9541 | |
| AU565 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 7794.016 | 0.9642 | 0.9630 | 1.9541 | |
| AU565 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 7794.016 | 0.5102 | 0.4173 | 1.9541 | |
| AU565 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 7794.016 | 0.0905 | -0.4152 | 1.9541 | |
| AU565 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 7794.016 | 0.1073 | -0.3618 | 1.9541 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7797.016 | 0.9522 | 0.8186 | 0.5155 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7797.016 | 1.0070 | 1.0273 | 0.5155 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7797.016 | 0.9821 | 0.9312 | 0.5155 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7797.016 | 0.9389 | 0.7698 | 0.5155 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7797.016 | 0.9083 | 0.6597 | 0.5155 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 7797.016 | 0.8033 | 0.3078 | 0.5155 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 7797.016 | 0.5858 | -0.2912 | 0.5155 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 7797.016 | 0.4325 | -0.6066 | 0.5155 | |
| BT-474 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 7797.016 | 0.3656 | -0.7160 | 0.5155 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7801.016 | 0.9408 | 0.7243 | 0.4118 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7801.016 | 0.9580 | 0.8019 | 0.4118 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7801.016 | 0.9847 | 0.9266 | 0.4118 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7801.016 | 1.0274 | 1.1358 | 0.4118 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7801.016 | 0.9977 | 0.9889 | 0.4118 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 7801.016 | 1.0183 | 1.0901 | 0.4118 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 7801.016 | 0.8980 | 0.5400 | 0.4118 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 7801.016 | 0.9589 | 0.8061 | 0.4118 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 7801.016 | 0.9270 | 0.6635 | 0.4118 | |
| BT-549 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.000427 | uM | 7803.016 | 1.0395 | 1.0276 | 2.8300 |