Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11056.135 | 0.5542 | 0.6377 | 2.9533 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11056.135 | 0.3735 | 0.4329 | 2.9533 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11056.135 | 0.2017 | 0.1631 | 2.9533 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11056.135 | 0.1872 | 0.1340 | 2.9533 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12254.135 | 0.9338 | 0.9193 | 1.6637 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12254.135 | 1.0201 | 1.0240 | 1.6637 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12254.135 | 1.0011 | 1.0014 | 1.6637 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12254.135 | 0.9597 | 0.9512 | 1.6637 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12254.135 | 0.8621 | 0.8294 | 1.6637 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12254.135 | 0.6632 | 0.5625 | 1.6637 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12254.135 | 0.4672 | 0.2659 | 1.6637 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12254.135 | 0.3686 | 0.0977 | 1.6637 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12254.135 | 0.3332 | 0.0331 | 1.6637 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10817.148 | 0.9788 | 0.9710 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10817.148 | 0.9498 | 0.9311 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10817.148 | 0.9383 | 0.9150 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10817.148 | 0.9461 | 0.9259 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10817.148 | 0.6994 | 0.5676 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10817.148 | 0.4632 | 0.1839 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10817.148 | 0.3614 | -0.0003 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10817.148 | 0.3256 | -0.0689 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10817.148 | 0.2935 | -0.1325 | 1.4678 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12365.135 | 0.9621 | 0.9654 | 2.2181 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12365.135 | 0.9682 | 0.9711 | 2.2181 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12365.135 | 0.9328 | 0.9383 | 2.2181 |