Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12305.135 | 0.0937 | -0.1678 | 2.6998 | |
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12305.135 | 0.0568 | -0.3086 | 2.6998 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10473.135 | 0.9900 | 0.9827 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10473.135 | 0.9908 | 0.9841 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10473.135 | 0.9468 | 0.9079 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10473.135 | 1.0262 | 1.0450 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10473.135 | 0.7494 | 0.5594 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10473.135 | 0.4432 | -0.0089 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10473.135 | 0.4123 | -0.0686 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10473.135 | 0.4387 | -0.0175 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10473.135 | 0.4616 | 0.0267 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10755.148 | 0.9161 | 0.7433 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10755.148 | 0.9049 | 0.7099 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10755.148 | 0.9208 | 0.7572 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10755.148 | 0.8574 | 0.5714 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10755.148 | 0.6845 | 0.1041 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10755.148 | 0.4458 | -0.4364 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10755.148 | 0.4466 | -0.4347 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10755.148 | 0.4358 | -0.4561 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10755.148 | 0.4579 | -0.4122 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12070.135 | 0.9400 | 0.9031 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12070.135 | 0.8901 | 0.8215 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12070.135 | 0.9740 | 0.9581 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12070.135 | 0.8509 | 0.7568 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12070.135 | 0.5336 | 0.2079 | 1.2457 |