Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7444.066 | 0.9407 | 0.8320 | 0.6972 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7444.066 | 0.6432 | 0.0620 | 0.6972 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7444.066 | 0.1717 | -0.8403 | 0.6972 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10441.066 | 0.9813 | 0.9677 | 1.1591 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 10441.066 | 0.9505 | 0.9142 | 1.1591 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 10441.066 | 0.9596 | 0.9301 | 1.1591 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 10441.066 | 0.9710 | 0.9498 | 1.1591 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 10441.066 | 0.9209 | 0.8628 | 1.1591 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 10441.066 | 0.9697 | 0.9477 | 1.1591 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 10441.066 | 0.9343 | 0.8861 | 1.1591 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 10441.066 | 0.8242 | 0.6928 | 1.1591 | |
| HCC1428 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 10441.066 | 0.3382 | -0.2150 | 1.1591 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7447.066 | 1.0544 | 1.0681 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.000427 | uM | 7447.066 | 1.0844 | 1.1051 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.00213 | uM | 7447.066 | 1.0547 | 1.0685 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0107 | uM | 7447.066 | 1.0329 | 1.0414 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0533 | uM | 7447.066 | 1.0475 | 1.0595 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.267 | uM | 7447.066 | 1.0352 | 1.0443 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 1.33 | uM | 7447.066 | 0.9943 | 0.9928 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 7447.066 | 1.0095 | 1.0120 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 33.3 | uM | 7447.066 | 0.9405 | 0.9240 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7448.066 | 0.9979 | 0.9984 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.000427 | uM | 7448.066 | 0.9625 | 0.9719 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.00213 | uM | 7448.066 | 0.9404 | 0.9550 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0107 | uM | 7448.066 | 1.0117 | 1.0086 | 2.7001 |