Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7464.084 | 0.9943 | 0.9860 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7464.084 | 1.0055 | 1.0134 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7464.084 | 1.0879 | 1.2177 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7464.084 | 0.9932 | 0.9834 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7464.084 | 0.9577 | 0.8968 | 0.8152 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7466.085 | 1.0152 | 1.0351 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7466.085 | 0.9493 | 0.8837 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7466.085 | 0.9733 | 0.9385 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7466.085 | 0.9494 | 0.8838 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7466.085 | 0.9977 | 0.9948 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7466.085 | 0.9865 | 0.9690 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7466.085 | 1.0094 | 1.0216 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7466.085 | 0.9838 | 0.9627 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7466.085 | 1.0105 | 1.0243 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7467.084 | 1.0127 | 1.0195 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7467.084 | 0.9794 | 0.9684 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7467.084 | 0.9844 | 0.9759 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7467.084 | 0.7375 | 0.5831 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7467.084 | 0.7141 | 0.5444 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7467.084 | 0.7684 | 0.6339 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7467.084 | 0.7576 | 0.6161 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7467.084 | 0.7740 | 0.6430 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7467.084 | 0.7960 | 0.6787 | 1.3029 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7468.085 | 0.9984 | 0.9978 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7468.085 | 0.9619 | 0.9468 | 1.4385 |