Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5911.084 | 0.7402 | 0.4918 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5911.084 | 0.7422 | 0.4958 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5911.084 | 0.7087 | 0.4299 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5911.084 | 0.6979 | 0.4086 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5911.084 | 0.6805 | 0.3744 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5912.084 | 0.9977 | 0.9958 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5912.084 | 0.9785 | 0.9608 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5912.084 | 0.9232 | 0.8594 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5912.084 | 0.6604 | 0.3700 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5912.084 | 0.7972 | 0.6266 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5912.084 | 0.6572 | 0.3639 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5912.084 | 0.6751 | 0.3978 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5912.084 | 0.6000 | 0.2552 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5912.084 | 0.6740 | 0.3956 | 1.0966 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7429.084 | 1.0293 | 1.0259 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7429.084 | 0.9735 | 0.9762 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7429.084 | 1.0235 | 1.0207 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7429.084 | 0.9283 | 0.9350 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7429.084 | 0.7282 | 0.7372 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7429.084 | 0.7757 | 0.7866 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7429.084 | 0.8272 | 0.8383 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7429.084 | 0.6806 | 0.6858 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 333 | uM | 7429.084 | 0.7991 | 0.8104 | 2.2510 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7430.085 | 1.0239 | 1.0242 | 1.9592 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7430.085 | 1.0450 | 1.0455 | 1.9592 |