Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12566.167 | 0.3447 | 0.0253 | 1.5941 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12566.167 | 0.0262 | -0.7962 | 1.5941 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12566.167 | 0.0105 | -0.8855 | 1.5941 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12224.154 | 0.9480 | 0.8917 | 0.9590 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12224.154 | 0.9688 | 0.9349 | 0.9590 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12224.154 | 0.9741 | 0.9460 | 0.9590 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12224.154 | 0.9891 | 0.9773 | 0.9590 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12224.154 | 0.9629 | 0.9227 | 0.9590 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12224.154 | 0.9929 | 0.9852 | 0.9590 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12224.154 | 0.8103 | 0.6061 | 0.9590 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12224.154 | 0.1489 | -0.7256 | 0.9590 | |
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12224.154 | 0.0116 | -0.9808 | 0.9590 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10880.154 | 0.9337 | 0.9246 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 10880.154 | 0.9571 | 0.9515 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 10880.154 | 0.9449 | 0.9376 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 10880.154 | 0.9764 | 0.9734 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 10880.154 | 0.8269 | 0.7980 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 10880.154 | 0.7845 | 0.7457 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 10880.154 | 0.6030 | 0.5065 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 10880.154 | 0.1612 | -0.2804 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 10880.154 | 0.0095 | -0.8526 | 1.7853 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000256 | uM | 10581.142 | 1.0665 | 1.1701 | 0.7885 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00128 | uM | 10581.142 | 0.9374 | 0.8424 | 0.7885 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0064 | uM | 10581.142 | 0.9780 | 0.9444 | 0.7885 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.032 | uM | 10581.142 | 0.9580 | 0.8941 | 0.7885 |