Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7545.098 | 0.9431 | 0.9011 | 1.1555 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7545.098 | 0.8957 | 0.8181 | 1.1555 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7545.098 | 0.8293 | 0.7009 | 1.1555 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7546.098 | 1.0047 | 1.0111 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7546.098 | 1.0364 | 1.0859 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7546.098 | 1.0013 | 1.0030 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7546.098 | 1.0750 | 1.1777 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7546.098 | 1.0163 | 1.0384 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7546.098 | 0.9846 | 0.9637 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7546.098 | 0.9057 | 0.7800 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7546.098 | 0.9760 | 0.9436 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7546.098 | 0.7129 | 0.3428 | 0.8495 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7547.098 | 0.9627 | 0.9283 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7547.098 | 0.7467 | 0.5103 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7547.098 | 0.9156 | 0.8373 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7547.098 | 0.8305 | 0.6728 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7547.098 | 0.9102 | 0.8270 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7547.098 | 0.8469 | 0.7046 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7547.098 | 0.6860 | 0.3919 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7547.098 | 0.4576 | -0.0571 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7547.098 | 0.4872 | 0.0015 | 1.0399 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7552.098 | 0.9639 | 0.9390 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7552.098 | 0.9166 | 0.8586 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7552.098 | 0.9385 | 0.8960 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7552.098 | 0.9753 | 0.9583 | 1.1882 |