Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7499.098 | 0.6984 | 0.1435 | 0.6421 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7500.098 | 0.9613 | 0.9010 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7500.098 | 0.9503 | 0.8728 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7500.098 | 1.0043 | 1.0111 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7500.098 | 1.0644 | 1.1673 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7500.098 | 1.0310 | 1.0801 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7500.098 | 0.9662 | 0.9134 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7500.098 | 0.8819 | 0.7011 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7500.098 | 0.4727 | -0.2378 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7500.098 | 0.3640 | -0.4556 | 0.7767 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7504.098 | 0.9738 | 0.9722 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7504.098 | 1.0789 | 1.0818 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7504.098 | 1.1342 | 1.1373 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7504.098 | 1.1455 | 1.1485 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7504.098 | 1.0415 | 1.0434 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7504.098 | 1.1544 | 1.1574 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7504.098 | 0.9737 | 0.9721 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7504.098 | 1.0380 | 1.0397 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7504.098 | 1.0752 | 1.0780 | 1.8959 | |
| MDA-MB-361 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7507.098 | 0.9885 | 0.9773 | 1.0164 | |
| MDA-MB-361 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7507.098 | 0.9306 | 0.8634 | 1.0164 | |
| MDA-MB-361 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7507.098 | 1.0148 | 1.0291 | 1.0164 | |
| MDA-MB-361 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7507.098 | 0.9855 | 0.9715 | 1.0164 | |
| MDA-MB-361 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7507.098 | 0.9623 | 0.9257 | 1.0164 | |
| MDA-MB-361 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7507.098 | 0.9497 | 0.9009 | 1.0164 |