Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7468.067 | 0.4786 | 0.1746 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 7468.067 | 0.2609 | -0.2420 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7468.067 | 0.2783 | -0.2059 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 7468.067 | 0.2669 | -0.2295 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 7468.067 | 0.0018 | -0.9792 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7469.067 | 0.9643 | 0.9651 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7469.067 | 0.9668 | 0.9675 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7469.067 | 0.9246 | 0.9255 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7469.067 | 1.0006 | 1.0006 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7469.067 | 0.4152 | 0.3063 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 7469.067 | 0.2701 | 0.0607 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7469.067 | 0.2933 | 0.1040 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 7469.067 | 0.2392 | 0.0000 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 7469.067 | 0.0025 | -0.8905 | 2.0639 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7470.067 | 1.0300 | 1.0557 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7470.067 | 0.9885 | 0.9786 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7470.067 | 0.9449 | 0.8975 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7470.067 | 1.0322 | 1.0597 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7470.067 | 0.4638 | -0.0199 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7470.067 | 0.2352 | -0.4780 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7470.067 | 0.2565 | -0.4342 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7470.067 | 0.1780 | -0.5969 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7470.067 | 0.0059 | -0.9830 | 1.0774 | |
| Hs 578T | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7473.067 | 1.0899 | 1.0655 | 2.6736 | |
| Hs 578T | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7473.067 | 1.1002 | 1.0727 | 2.6736 |