Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 5909.067 | 0.0011 | -0.8153 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5910.067 | 1.0911 | 1.0542 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5910.067 | 1.1611 | 1.0937 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5910.067 | 1.1413 | 1.0827 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5910.067 | 1.0614 | 1.0368 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5910.067 | 0.3526 | 0.4531 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 5910.067 | 0.3029 | 0.3869 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 5910.067 | 0.2817 | 0.3564 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 5910.067 | 0.2463 | 0.3017 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 5910.067 | 0.0004 | -0.8117 | 3.2630 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5911.067 | 1.0166 | 1.0330 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5911.067 | 0.9707 | 0.9417 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5911.067 | 1.0005 | 1.0011 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5911.067 | 0.9608 | 0.9218 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5911.067 | 0.2265 | -0.5445 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5911.067 | 0.2185 | -0.5605 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5911.067 | 0.2283 | -0.5409 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5911.067 | 0.1634 | -0.6711 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5911.067 | 0.0063 | -0.9872 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5912.067 | 0.9579 | 0.9280 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5912.067 | 0.9532 | 0.9199 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5912.067 | 0.9659 | 0.9417 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5912.067 | 0.9828 | 0.9706 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5912.067 | 0.1708 | -0.5570 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5912.067 | 0.1675 | -0.5644 | 1.1725 |