Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7879.001 | 0.3057 | 0.0571 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7879.001 | 0.2422 | -0.0674 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7879.001 | 0.2138 | -0.1279 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7879.001 | 0.2521 | -0.0470 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7879.001 | 0.3269 | 0.0959 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7879.001 | 0.2737 | -0.0038 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7879.001 | 0.1417 | -0.3010 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10093.001 | 0.9417 | 0.8020 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10093.001 | 1.0896 | 1.3212 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10093.001 | 1.2519 | 1.9541 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10093.001 | 0.2244 | -0.8506 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10093.001 | 0.0701 | -0.9802 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 10093.001 | 0.2345 | -0.8388 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 10093.001 | 0.1256 | -0.9455 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 10093.001 | 0.1687 | -0.9090 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 10093.001 | 0.0074 | -0.9996 | 0.5759 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7884.001 | 1.0119 | 1.0444 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7884.001 | 1.0223 | 1.0839 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7884.001 | 0.8105 | 0.3518 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7884.001 | 0.6574 | -0.0851 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7884.001 | 0.6889 | -0.0016 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7884.001 | 0.8996 | 0.6421 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7884.001 | 0.9563 | 0.8402 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7884.001 | 0.7981 | 0.3135 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7884.001 | 0.3349 | -0.7398 | 0.5364 |