Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7857.001 | 0.9804 | 0.9665 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7857.001 | 1.0706 | 1.1198 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7857.001 | 0.8838 | 0.8000 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7857.001 | 0.9577 | 0.9277 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7857.001 | 0.4071 | -0.0708 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7857.001 | 0.6388 | 0.3645 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7857.001 | 0.7265 | 0.5228 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7857.001 | 0.5266 | 0.1574 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7857.001 | 0.1993 | -0.4947 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9501.001 | 1.0744 | 1.1492 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9501.001 | 1.1096 | 1.2199 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9501.001 | 1.0276 | 1.0554 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9501.001 | 1.0213 | 1.0427 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9501.001 | 0.5557 | 0.1094 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 9501.001 | 0.5869 | 0.1718 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 9501.001 | 0.7027 | 0.4039 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 9501.001 | 0.4643 | -0.0736 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 9501.001 | 0.0131 | -0.9742 | 0.9969 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7911.001 | 0.9968 | 0.9947 | 1.2005 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7911.001 | 1.1775 | 1.2916 | 1.2005 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7911.001 | 0.8706 | 0.7820 | 1.2005 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7911.001 | 0.2522 | -0.3652 | 1.2005 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7911.001 | 0.3073 | -0.2516 | 1.2005 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 0.267 | uM | 7911.001 | 0.3074 | -0.2514 | 1.2005 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 1.33 | uM | 7911.001 | 0.5167 | 0.1538 | 1.2005 |