Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7500.098 | 0.9411 | 0.8496 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7500.098 | 1.0256 | 1.0663 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7500.098 | 0.9851 | 0.9618 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7500.098 | 0.9653 | 0.9110 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7500.098 | 0.7073 | 0.2805 | 0.7767 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7500.098 | 0.8725 | 0.6778 | 0.7767 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000307 | uM | 7504.071 | 0.9868 | 0.9876 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00154 | uM | 7504.071 | 1.1447 | 1.1299 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00768 | uM | 7504.071 | 0.9390 | 0.9422 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.0384 | uM | 7504.071 | 0.9156 | 0.9196 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.192 | uM | 7504.071 | 1.0179 | 1.0166 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.96 | uM | 7504.071 | 0.9351 | 0.9385 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 4.8 | uM | 7504.071 | 0.9876 | 0.9884 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 24 | uM | 7504.071 | 0.0179 | -0.6924 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 120 | uM | 7504.071 | 0.0098 | -0.7676 | 2.1484 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7504.091 | 1.0097 | 1.0097 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7504.091 | 0.9315 | 0.9301 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7504.091 | 0.9319 | 0.9305 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7504.091 | 0.9354 | 0.9341 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7504.091 | 1.0377 | 1.0375 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7504.091 | 0.9608 | 0.9603 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7504.091 | 0.6994 | 0.6718 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7504.091 | 0.8040 | 0.7928 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 133 | uM | 7504.091 | 0.0086 | -0.8160 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7504.098 | 0.9952 | 0.9950 | 1.8959 |