Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7458.098 | 1.0299 | 1.1053 | 0.5731 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7458.098 | 1.0047 | 1.0165 | 0.5731 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7458.098 | 0.9846 | 0.9465 | 0.5731 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7458.098 | 0.9993 | 0.9975 | 0.5731 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7458.098 | 0.9757 | 0.9158 | 0.5731 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7458.098 | 0.9900 | 0.9653 | 0.5731 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7458.098 | 0.5313 | -0.3366 | 0.5731 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7458.098 | 0.0114 | -0.9992 | 0.5731 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7462.092 | 1.0141 | 1.0656 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7462.092 | 0.9720 | 0.8733 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7462.092 | 1.0159 | 1.0743 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7462.092 | 1.0269 | 1.1261 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7462.092 | 0.9942 | 0.9732 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7462.092 | 1.0069 | 1.0319 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7462.092 | 0.9063 | 0.5938 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7462.092 | 0.3684 | -0.8001 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7462.092 | 0.1349 | -0.9803 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7463.07 | 0.9614 | 0.8698 | 0.5848 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7463.07 | 0.9865 | 0.9541 | 0.5848 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7463.07 | 0.9789 | 0.9283 | 0.5848 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7463.07 | 0.9986 | 0.9953 | 0.5848 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7463.07 | 0.9542 | 0.8458 | 0.5848 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7463.07 | 0.9525 | 0.8403 | 0.5848 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7463.07 | 0.7934 | 0.3465 | 0.5848 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7463.07 | 0.3920 | -0.5969 | 0.5848 |