Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7920.001 | 0.6486 | 0.8129 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7920.001 | 0.6645 | 0.8229 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7920.001 | 0.4004 | 0.6250 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7920.001 | 0.0373 | -0.0516 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9844.001 | 1.0818 | 1.0678 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 9844.001 | 0.9873 | 0.9892 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9844.001 | 1.0897 | 1.0742 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9844.001 | 0.9910 | 0.9923 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 9844.001 | 0.7619 | 0.7822 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 9844.001 | 0.7087 | 0.7283 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 9844.001 | 0.6351 | 0.6499 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 9844.001 | 0.3626 | 0.3008 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 9844.001 | 0.0320 | -0.5353 | 2.3587 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10146.001 | 1.0146 | 1.0397 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10146.001 | 1.0380 | 1.1040 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10146.001 | 1.1113 | 1.3084 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10146.001 | 1.0937 | 1.2590 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10146.001 | 1.1409 | 1.3926 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 10146.001 | 1.0067 | 1.0183 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 10146.001 | 0.7222 | 0.2849 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 10146.001 | 0.3083 | -0.5961 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 10146.001 | 0.0104 | -0.9960 | 0.7356 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9860.001 | 0.9841 | 0.9802 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.000427 | uM | 9860.001 | 1.0357 | 1.0439 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.00213 | uM | 9860.001 | 1.0071 | 1.0088 | 1.6119 |