Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7886.001 | 1.0339 | 1.0852 | 0.7999 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7886.001 | 1.0068 | 1.0170 | 0.7999 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7886.001 | 0.9967 | 0.9917 | 0.7999 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7886.001 | 0.8859 | 0.7190 | 0.7999 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7886.001 | 0.9194 | 0.8005 | 0.7999 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7886.001 | 0.9366 | 0.8428 | 0.7999 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7886.001 | 1.0262 | 1.0658 | 0.7999 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7886.001 | 0.9276 | 0.8206 | 0.7999 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7886.001 | 0.1022 | -0.8844 | 0.7999 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7892.001 | 0.9265 | 0.9428 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 7892.001 | 1.0058 | 1.0044 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 7892.001 | 1.0304 | 1.0229 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 7892.001 | 0.8740 | 0.9002 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 7892.001 | 0.8110 | 0.8470 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7892.001 | 0.7866 | 0.8256 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7892.001 | 0.6929 | 0.7398 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7892.001 | 0.3357 | 0.3210 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7892.001 | 0.0015 | -0.8290 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7893.001 | 1.0243 | 1.0210 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 7893.001 | 0.9732 | 0.9765 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 7893.001 | 0.9775 | 0.9803 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 7893.001 | 0.9039 | 0.9142 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 7893.001 | 0.9560 | 0.9613 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7893.001 | 0.9164 | 0.9257 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7893.001 | 0.7913 | 0.8068 | 2.3044 |