Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 9254.001 | 1.3168 | 2.9895 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 9254.001 | 1.2923 | 2.8058 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 9254.001 | 1.1841 | 2.0562 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 9254.001 | 0.7631 | 0.0148 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 9254.001 | 0.0010 | -1.0000 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9258.001 | 0.8918 | 0.7035 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 9258.001 | 0.9804 | 0.9454 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9258.001 | 0.9639 | 0.8995 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9258.001 | 0.8841 | 0.6829 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 9258.001 | 0.7539 | 0.3463 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 9258.001 | 0.7727 | 0.3935 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 9258.001 | 0.7372 | 0.3047 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 9258.001 | 0.4616 | -0.3229 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 9258.001 | 0.0318 | -0.9841 | 0.7137 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7819.001 | 1.0460 | 1.1916 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7819.001 | 0.9671 | 0.8684 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7819.001 | 1.0440 | 1.1829 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7819.001 | 0.9375 | 0.7543 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7819.001 | 1.0497 | 1.2073 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7819.001 | 0.9543 | 0.8187 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7819.001 | 0.9380 | 0.7559 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7819.001 | 0.8574 | 0.4630 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7819.001 | 0.6687 | -0.1173 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7820.001 | 1.0639 | 1.1678 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7820.001 | 0.9535 | 0.8800 | 0.7692 |