Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.0213 | uM | 12098.16 | 1.0366 | 1.0765 | 0.9575 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12098.16 | 0.9721 | 0.9417 | 0.9575 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.533 | uM | 12098.16 | 1.0870 | 1.1820 | 0.9575 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 2.67 | uM | 12098.16 | 1.1401 | 1.2936 | 0.9575 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12098.16 | 0.9911 | 0.9813 | 0.9575 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 66.7 | uM | 12098.16 | 0.9093 | 0.8109 | 0.9575 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 11058.15 | 0.9028 | 0.9118 | 2.2684 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 11058.15 | 1.0443 | 1.0386 | 2.2684 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 11058.15 | 0.9362 | 0.9427 | 2.2684 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 11058.15 | 1.0309 | 1.0270 | 2.2684 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 11058.15 | 0.9097 | 0.9183 | 2.2684 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 11058.15 | 0.9395 | 0.9457 | 2.2684 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 11058.15 | 0.8400 | 0.8521 | 2.2684 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 11058.15 | 0.5351 | 0.5182 | 2.2684 | ||
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 11058.15 | 0.3475 | 0.2551 | 2.2684 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10695.15 | 1.0042 | 1.0062 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10695.15 | 0.9785 | 0.9680 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10695.15 | 0.9732 | 0.9603 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 10695.15 | 0.9573 | 0.9365 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 10695.15 | 1.0070 | 1.0104 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10695.15 | 1.0147 | 1.0217 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 10695.15 | 0.9118 | 0.8680 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 10695.15 | 0.5928 | 0.3586 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10695.15 | 0.3490 | -0.0819 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 11852.16 | 0.9149 | 0.8614 | 1.2383 |