Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7902.075 | 0.3496 | 0.1695 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7902.075 | 0.3881 | 0.2335 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7902.075 | 0.3540 | 0.1770 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 722 | uM | 7902.075 | 0.3374 | 0.1485 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 10266.011 | 1.1113 | 1.3309 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 10266.011 | 0.9502 | 0.8572 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 10266.011 | 1.0046 | 1.0132 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 10266.011 | 0.5311 | -0.2011 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 10266.011 | 0.5007 | -0.2666 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 10266.011 | 0.4671 | -0.3370 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 10266.011 | 0.4440 | -0.3839 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 10266.011 | 0.4118 | -0.4476 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 10266.011 | 0.3594 | -0.5466 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0185 | uM | 10266.131 | 0.5185 | -0.0722 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0924 | uM | 10266.131 | 0.4662 | -0.1806 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.462 | uM | 10266.131 | 0.4643 | -0.1846 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 2.31 | uM | 10266.131 | 0.3937 | -0.3276 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 11.6 | uM | 10266.131 | 0.4064 | -0.3022 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 57.8 | uM | 10266.131 | 0.3432 | -0.4272 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 289 | uM | 10266.131 | 0.3882 | -0.3386 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 1440 | uM | 10266.131 | 0.3332 | -0.4468 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7220 | uM | 10266.131 | 0.0108 | -0.9900 | 0.8552 | |
| MDA-MB-453 | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7903.011 | 0.9525 | 0.9173 | 1.1535 | |
| MDA-MB-453 | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7903.011 | 1.0361 | 1.0624 | 1.1535 | |
| MDA-MB-453 | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7903.011 | 0.7729 | 0.5997 | 1.1535 |