Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Linsitinib | 7 | 625.00 | 0.7659 | 0.7659 | 0.1095 | 0.0000 | 0.7181 | 0.5839 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8841 | 4.7091 | 2.0244 | 0.3465 | 0.2516 | 0.8285 | 0.2347 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9223 |
| MCF 10A | Linsitinib | 7 | 1250.00 | 2.042 | 1.4648 | 0.2017 | 0.1444 | 1.0257 | 0.7246 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9773 | 15.1223 | 3.0546 | 0.4868 | 0.3967 | 0.9858 | 0.1477 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9877 |
| MCF 10A | Linsitinib | 7 | 2500.00 | 2.8239 | 1.5884 | 0.2889 | 0.2214 | 1.0161 | 0.7585 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9833 | 18.5386 | 2.5766 | 0.5110 | 0.4380 | 1.0574 | 0.1453 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9868 |
| MCF 10A | Linsitinib | 7 | 5000.00 | inf | 3.6437 | 0.5826 | 0.4998 | 0.8930 | 0.8789 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9535 | inf | 3.2481 | 0.7755 | 0.7670 | 1.2141 | 0.0586 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9353 |
| MCF 10A | 17-AAG | 7 | 156.25 | 0.0033 | 0.0023 | 0.1600 | 0.1919 | 1.3617 | 0.2562 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9506 | 0.0055 | 0.0035 | 0.1624 | 0.2000 | 1.0962 | 0.7063 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9051 |
| MCF 10A | 17-AAG | 7 | 312.50 | 0.0035 | 0.0034 | 0.0500 | 0.0695 | 5.0000 | 0.1602 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9889 | 0.0062 | 0.0057 | 0.0685 | 0.1019 | 2.4094 | 0.7676 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9836 |
| MCF 10A | 17-AAG | 7 | 625.00 | 0.007 | 0.0069 | 0.0320 | 0.0324 | 2.7824 | 0.1925 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9978 | 0.0121 | 0.0109 | 0.1403 | 0.1362 | 2.9735 | 0.6798 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9904 |
| MCF 10A | 17-AAG | 7 | 1250.00 | 0.012 | 0.0116 | 0.0470 | 0.0485 | 3.4403 | 0.2662 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9983 | 0.0185 | 0.0166 | 0.1365 | 0.1352 | 2.9129 | 0.6362 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.995 |
| MCF 10A | 17-AAG | 7 | 2500.00 | 0.0144 | 0.0138 | 0.0698 | 0.0611 | 3.1227 | 0.2933 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9991 | 0.0198 | 0.0189 | 0.1107 | 0.0694 | 2.9083 | 0.6733 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.99 |
| MCF 10A | 17-AAG | 7 | 5000.00 | 0.0344 | 0.0305 | 0.2424 | 0.2159 | 4.7028 | 0.4682 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9917 | 0.0519 | 0.0342 | 0.4915 | 0.4383 | 5.0000 | 0.3708 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9563 |
| MCF 10A | Lapatinib | 8 | 156.25 | 3.1161 | 2.959 | 0.1162 | 0.1139 | 5.0000 | 0.9132 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.981 | 3.6794 | 3.4241 | 0.1550 | 0.1510 | 5.0000 | 0.0635 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.979 |
| MCF 10A | Lapatinib | 8 | 312.50 | 2.7483 | 2.6727 | 0.0674 | 0.0651 | 5.0000 | 0.8839 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.986 | 3.1219 | 3.2028 | -0.0646 | -0.0682 | 5.0000 | 0.1115 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9885 |
| MCF 10A | Lapatinib | 8 | 625.00 | 2.3401 | 2.2784 | 0.0506 | 0.0464 | 3.6488 | 0.8477 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9873 | 2.9743 | 3.0547 | -0.0256 | -0.0460 | 3.3009 | 0.1309 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9918 |
| MCF 10A | Lapatinib | 8 | 1250.00 | 2.5454 | 2.4939 | 0.0523 | 0.0254 | 2.5493 | 0.8589 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9917 | 3.5441 | 3.9385 | -0.0247 | -0.1402 | 2.3422 | 0.1204 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9969 |
| MCF 10A | Lapatinib | 8 | 2500.00 | 3.65 | 3.65 | 0.1019 | 0.0000 | 2.1330 | 0.8865 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9971 | 4.366 | 5.7003 | -0.0205 | -0.3522 | 1.9994 | 0.1088 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9991 |
| MCF 10A | Lapatinib | 8 | 5000.00 | 5.3066 | 5.3066 | 0.2845 | 0.0000 | 1.2970 | 0.8911 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9886 | 6.8624 | 18.0296 | 0.3184 | -1.0000 | 1.1373 | 0.0897 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9956 |
| MCF 10A | Erlotinib | 8 | 156.25 | 0.8069 | 0.7268 | 0.2017 | 0.2035 | 5.0000 | 0.7200 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9905 | 1.0063 | 0.8078 | 0.3327 | 0.3334 | 5.0000 | 0.2220 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.987 |
| MCF 10A | Erlotinib | 8 | 312.50 | 0.6518 | 0.6165 | 0.1078 | 0.1215 | 4.9998 | 0.6643 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9954 | 0.724 | 0.6858 | 0.0752 | 0.1087 | 4.5259 | 0.3378 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9954 |
| MCF 10A | Erlotinib | 8 | 625.00 | 0.5087 | 0.4851 | 0.0722 | 0.0790 | 3.6044 | 0.6165 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9951 | 0.6571 | 0.6226 | 0.0627 | 0.0815 | 3.3005 | 0.3626 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9982 |
| MCF 10A | Erlotinib | 8 | 1250.00 | 0.4797 | 0.4594 | 0.0702 | 0.0757 | 3.7957 | 0.6159 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9969 | 0.611 | 0.5865 | 0.0514 | 0.0665 | 3.4909 | 0.3721 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.999 |
| MCF 10A | Erlotinib | 8 | 2500.00 | 0.5584 | 0.5104 | 0.1310 | 0.1336 | 3.4617 | 0.6403 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9994 | 0.6435 | 0.6148 | 0.0654 | 0.0706 | 3.3344 | 0.3702 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9998 |
| MCF 10A | Erlotinib | 8 | 5000.00 | 0.7739 | 0.4639 | 0.3075 | 0.3235 | 2.0339 | 0.7047 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9988 | 1.1129 | 0.5498 | 0.3564 | 0.3792 | 2.0147 | 0.2573 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9981 |
| MCF 10A | Linsitinib | 8 | 156.25 | 0.9778 | 0.8158 | 0.1883 | 0.2979 | 5.0000 | 0.7290 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8866 | 4.0857 | 1.3761 | 0.3096 | 0.3586 | 1.1607 | 0.1875 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8825 |
| MCF 10A | Linsitinib | 8 | 312.50 | 0.9851 | 0.8545 | 0.1342 | 0.2024 | 3.6462 | 0.7025 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9696 | 1.5647 | 1.1147 | 0.1406 | 0.2215 | 1.7253 | 0.2513 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9698 |
| MCF 10A | Linsitinib | 8 | 625.00 | 0.6573 | 0.5077 | 0.1110 | 0.1215 | 1.0779 | 0.6361 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9844 | 1.8565 | 1.1945 | 0.1780 | 0.1675 | 0.9248 | 0.2650 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9817 |