Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | PLX-4720 | 5 | 2500.00 | inf | inf | 0.9852 | 0.9852 | 0.0000 | 1.0390 | flat fit: x = Einf | -2.6214 | inf | inf | 0.9848 | 0.9848 | 0.0000 | -0.0382 | flat fit: x = Einf | -2.3954 |
| MCF 10A | PLX-4720 | 5 | 5000.00 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0333 | flat fit: x = Einf | -3.1864 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0329 | flat fit: x = Einf | -3.1167 |
| MCF 10A | Palbociclib | 5 | 156.25 | 0.1018 | 0.0977 | 0.0560 | 0.0162 | 0.8044 | 0.4034 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9577 | 0.3959 | 0.2525 | 0.2019 | 0.1599 | 0.8569 | 0.4296 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9701 |
| MCF 10A | Palbociclib | 5 | 312.50 | 0.15 | 0.1367 | 0.0472 | 0.0561 | 1.2777 | 0.4637 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9878 | 0.3998 | 0.3258 | 0.0706 | 0.0981 | 1.0678 | 0.4205 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9939 |
| MCF 10A | Palbociclib | 5 | 625.00 | 0.2381 | 0.1967 | 0.0743 | 0.0877 | 1.0097 | 0.5210 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9963 | 0.8735 | 0.6786 | 0.1195 | 0.0893 | 0.7788 | 0.3548 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.994 |
| MCF 10A | Palbociclib | 5 | 1250.00 | 0.3695 | 0.2473 | 0.1398 | 0.1395 | 0.8141 | 0.5694 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9971 | 0.9382 | 0.7121 | 0.1326 | 0.0879 | 0.7014 | 0.3552 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9952 |
| MCF 10A | Palbociclib | 5 | 2500.00 | 0.3641 | 0.1766 | 0.2468 | 0.2295 | 0.8490 | 0.5800 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9988 | 0.2996 | 0.269 | 0.0681 | 0.0444 | 0.8609 | 0.4780 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9983 |
| MCF 10A | Palbociclib | 5 | 5000.00 | 0.7659 | 0.068 | 0.4426 | 0.4219 | 0.7667 | 0.6210 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9281 | 0.2868 | 0.0857 | 0.3417 | 0.3201 | 0.8465 | 0.4347 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9215 |
| MCF 10A | Nilotinib | 5 | 156.25 | 5.0857 | 4.6188 | 0.1438 | 0.1911 | 5.0000 | 0.8968 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.981 | 10.0723 | 4.8248 | 0.4213 | 0.4874 | 5.0000 | 0.0591 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9531 |
| MCF 10A | Nilotinib | 5 | 312.50 | 6.702 | 6.3562 | 0.1182 | 0.1152 | 4.9426 | 0.9098 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9896 | 9.1467 | 7.6312 | 0.2935 | 0.2857 | 4.6773 | 0.0732 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9956 |
| MCF 10A | Nilotinib | 5 | 625.00 | 7.3999 | 7.1049 | 0.0916 | 0.0823 | 4.4173 | 0.9028 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9949 | 9.3348 | 8.5811 | 0.1737 | 0.1520 | 4.3051 | 0.0842 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9986 |
| MCF 10A | Nilotinib | 5 | 1250.00 | 11.2764 | 10.4061 | 0.2029 | 0.1234 | 3.5295 | 0.9403 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9936 | 13.0509 | 12.7592 | 0.2048 | 0.0377 | 3.4706 | 0.0537 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9977 |
| MCF 10A | Nilotinib | 5 | 2500.00 | 13.7182 | 12.2151 | 0.2812 | 0.2196 | 4.9835 | 0.9799 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9802 | 12.9766 | 13.1234 | 0.0859 | -0.0285 | 4.9315 | 0.0299 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9884 |
| MCF 10A | Nilotinib | 5 | 5000.00 | 19.1943 | 19.1943 | 0.4363 | 0.0000 | 5.0000 | 1.0042 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9549 | 18.4273 | 22.9555 | 0.3260 | -1.0000 | 5.0000 | 0.0008 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9711 |
| MCF 10A | Taxol | 5 | 156.25 | 0.0015 | 0.0015 | 0.0443 | 0.0484 | 2.3153 | 0.2919 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9966 | 0.0029 | 0.0024 | 0.1562 | 0.1638 | 2.0155 | 0.5776 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9911 |
| MCF 10A | Taxol | 5 | 312.50 | 0.0014 | 0.0013 | 0.0310 | 0.0374 | 2.6505 | 0.2751 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9961 | 0.0022 | 0.0022 | -0.0179 | -0.0010 | 2.1391 | 0.6985 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9975 |
| MCF 10A | Taxol | 5 | 625.00 | 0.0019 | 0.0019 | 0.0345 | 0.0351 | 2.5564 | 0.3102 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.996 | 0.0029 | 0.003 | -0.0558 | -0.0535 | 2.3707 | 0.7003 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9983 |
| MCF 10A | Taxol | 5 | 1250.00 | 0.0031 | 0.003 | 0.0544 | 0.0578 | 2.8757 | 0.3724 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9996 | 0.0039 | 0.0043 | -0.1340 | -0.1233 | 2.4543 | 0.7018 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9995 |
| MCF 10A | Taxol | 5 | 2500.00 | 0.0048 | 0.0043 | 0.1052 | 0.1108 | 2.2501 | 0.4422 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9987 | 0.0046 | 0.0056 | -0.2714 | -0.2558 | 2.0992 | 0.7487 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9988 |
| MCF 10A | Taxol | 5 | 5000.00 | 0.0126 | 0.009 | 0.2215 | 0.2193 | 1.6977 | 0.5742 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.999 | 0.0105 | 0.0111 | -0.0437 | -0.0449 | 1.7160 | 0.5448 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9993 |
| MCF 10A | Omipalisib | 5 | 156.25 | 0.0027 | 0.0025 | 0.0397 | 0.0324 | 0.6992 | 0.1682 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9826 | 0.0183 | 0.0112 | 0.1317 | 0.1477 | 0.7187 | 0.6313 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9837 |
| MCF 10A | Omipalisib | 5 | 312.50 | 0.0014 | 0.0013 | 0.0316 | 0.0174 | 0.5893 | 0.1396 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9569 | 0.0083 | 0.0085 | -0.0156 | -0.0064 | 0.6581 | 0.7623 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9703 |
| MCF 10A | Omipalisib | 5 | 625.00 | 0.0038 | 0.0035 | 0.0358 | 0.0417 | 0.8566 | 0.1796 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9968 | 0.0127 | 0.0131 | -0.0478 | -0.0116 | 0.7574 | 0.7394 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9937 |
| MCF 10A | Omipalisib | 5 | 1250.00 | 0.0092 | 0.0076 | 0.0668 | 0.0858 | 0.9993 | 0.2700 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9954 | 0.0165 | 0.0168 | -0.0812 | -0.0087 | 0.9385 | 0.7201 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9888 |
| MCF 10A | Omipalisib | 5 | 2500.00 | 0.0226 | 0.0143 | 0.1586 | 0.2203 | 1.2638 | 0.4235 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9887 | 0.0206 | 0.0205 | -0.1241 | 0.0015 | 1.1182 | 0.6924 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9768 |