LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 658 | 25 | 3933 | 0.0064 | -0.7202 |
| Hs 578T | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 658 | 35 | 3761 | 0.0093 | -0.6912 |
| Hs 578T | PHA-665752 | 10 | uM | LJP5 | 72 | hr | 658 | 53 | 3933 | 0.0136 | -0.6240 |
| MCF 10A | AZD8055 | 10 | uM | LJP6 | 72 | hr | 962 | 57 | 10692 | 0.0053 | -0.5572 |
| MCF7 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1209 | 70 | 4012 | 0.0175 | -0.8076 |
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 1235 | 86 | 4660 | 0.0186 | -0.7515 |
| MCF7 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 1209 | 89 | 4203 | 0.0213 | -0.7655 |
| SK-BR-3 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 1401 | 91 | 4245 | 0.0217 | -0.8201 |
| Hs 578T | AZD8055 | 10 | uM | LJP6 | 72 | hr | 658 | 103 | 3761 | 0.0276 | -0.5223 |
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1235 | 108 | 4405 | 0.0247 | -0.7348 |
| SK-BR-3 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1401 | 109 | 4168 | 0.0261 | -0.8036 |
| BT-20 | AZD8055 | 10 | uM | LJP6 | 72 | hr | 1097 | 119 | 3673 | 0.0326 | -0.7198 |
| Hs 578T | SB590885 | 10 | uM | LJP5 | 72 | hr | 658 | 125 | 3933 | 0.0320 | -0.4740 |
| MDA-MB-231 | PHA-665752 | 10 | uM | LJP5 | 72 | hr | 1235 | 131 | 4660 | 0.0282 | -0.6902 |
| MCF 10A | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 962 | 136 | 10512 | 0.0130 | -0.4374 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 658 | 147 | 3761 | 0.0393 | -0.4481 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 658 | 154 | 3933 | 0.0392 | -0.4301 |
| BT-20 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 1097 | 158 | 3846 | 0.0411 | -0.6586 |
| MCF7 | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 1209 | 170 | 4012 | 0.0422 | -0.6806 |
| MCF 10A | A443654 | 10 | uM | LJP6 | 72 | hr | 962 | 173 | 10692 | 0.0162 | -0.3911 |
| Hs 578T | LDN-193189 | 3.33 | uM | LJP5 | 72 | hr | 658 | 183 | 3933 | 0.0465 | -0.3919 |
| Hs 578T | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 658 | 184 | 3761 | 0.0492 | -0.3976 |
| MCF 10A | WZ3105 | 10 | uM | LJP5 | 72 | hr | 962 | 185 | 10512 | 0.0176 | -0.3840 |
| MDA-MB-231 | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 1235 | 185 | 4660 | 0.0399 | -0.6288 |
| Hs 578T | WH-4-025 | 10 | uM | LJP5 | 72 | hr | 658 | 186 | 3933 | 0.0473 | -0.3913 |