LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
SK-BR-3 Withaferin A
1.11
uM
LJP6
 72
hr
 1401 1291 4168 0.3101 -0.0504
SK-BR-3 Withaferin A
3.33
uM
LJP5
 72
hr
 1401 931 4245 0.2200 -0.2263
SK-BR-3 Withaferin A
3.33
uM
LJP6
 72
hr
 1401 985 4168 0.2364 -0.2016
SK-BR-3 Withaferin A
10
uM
LJP5
 72
hr
 1401 1018 4245 0.2411 -0.1811
SK-BR-3 Withaferin A
10
uM
LJP6
 72
hr
 1401 1153 4168 0.2766 -0.1177
MDA-MB-231 Seliciclib
0.04
uM
LJP5
 72
hr
 1235 4659 4660 0.9984 0.9970
MDA-MB-231 Seliciclib
0.12
uM
LJP5
 72
hr
 1235 4391 4660 0.9412 0.9367
MDA-MB-231 Seliciclib
0.37
uM
LJP5
 72
hr
 1235 4369 4660 0.9370 0.9328
MDA-MB-231 Seliciclib
1.11
uM
LJP5
 72
hr
 1235 4116 4660 0.8818 0.8711
MDA-MB-231 Seliciclib
3.33
uM
LJP5
 72
hr
 1235 3754 4660 0.8047 0.7842
MDA-MB-231 Seliciclib
10
uM
LJP5
 72
hr
 1235 2463 4660 0.5278 0.4310
MDA-MB-231 AT-7519
0.04
uM
LJP6
 72
hr
 1235 2660 4405 0.6042 0.5194
MDA-MB-231 AT-7519
0.12
uM
LJP6
 72
hr
 1235 947 4405 0.2148 -0.1388
MDA-MB-231 AT-7519
0.37
uM
LJP6
 72
hr
 1235 496 4405 0.1125 -0.3929
MDA-MB-231 AT-7519
1.11
uM
LJP6
 72
hr
 1235 324 4405 0.0730 -0.5262
MDA-MB-231 AT-7519
3.33
uM
LJP6
 72
hr
 1235 283 4405 0.0637 -0.5629
MDA-MB-231 AT-7519
10
uM
LJP6
 72
hr
 1235 259 4405 0.0584 -0.5826
MDA-MB-231 AZD7762
0.04
uM
LJP6
 72
hr
 1235 3180 4405 0.7227 0.6749
MDA-MB-231 AZD7762
0.12
uM
LJP6
 72
hr
 1235 2007 4405 0.4560 0.3028
MDA-MB-231 AZD7762
0.37
uM
LJP6
 72
hr
 1235 1162 4405 0.2631 -0.0361
MDA-MB-231 AZD7762
1.11
uM
LJP6
 72
hr
 1235 729 4405 0.1653 -0.2512
MDA-MB-231 AZD7762
3.33
uM
LJP6
 72
hr
 1235 497 4405 0.1131 -0.3916
MDA-MB-231 AZD7762
10
uM
LJP6
 72
hr
 1235 409 4405 0.0926 -0.4545
MDA-MB-231 AZD8055
0.04
uM
LJP6
 72
hr
 1235 2611 4405 0.5930 0.5025
MDA-MB-231 AZD8055
0.12
uM
LJP6
 72
hr
 1235 2180 4405 0.4954 0.3614